Peripheral blood monocytes from bone marrow are
recruited locally and differentiate into TAMs in response
to chemokines and growth factors produced by stromal
and tumor cells in the tumor microenvironment
macrophages,
whether they are derived from the yolk sac or
bone marrow 8. In a polyoma middle T oncoprotein
model, the binding of chemokine (C-C motif) ligand
(CCL) 2 to chemokine (C-C motif) receptor (CCR) 2
directly mediated monocyte recruitment to the primary
tumor and metastases 9. In a xenograft model, vascular
endothelial growth factor A (VEGFA) recruited monocytes
that differentiated into TAMs in the presence of
IL-4 and the absence of these TAMs inhibited tumor
growth, invasion, proliferation, and angiogenesis 10. In
human breast cancer models, binding of CCL18 to its
receptor PITPNM3 mediated the recruitment of macrophages
in collaboration with CSF2 11. In colon cancer

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