Fortunately, when the liver is exposed to an acute injury, it can restore its original architecture in a relatively short period even when a large part of the organ is destroyed. On the other hand, chronic liver injury induces repetitive tissue damage, resulting in restricted regenerative capacity with inflammatory infiltrate and a chronic wound healing response. The response to chronic injury also includes necrosis and/or apoptosis of parenchymal cells and their replacement by extracellular matrix (ECM) .
The tenascins are a highly conserved family of large oligomeric glycoproteins found in the extracellular matrix (ECM) of vertebrate organisms. The family contains four family members: tenascin-X, tenascin-R, tenascin-W, and tenascin-C

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